Neurological follow-up for premature babies

Assessment by corrected age, risk factors, a follow-up schedule for the first 2 years and early intervention.

A baby born before the 37th week of pregnancy is considered premature (preterm). Because the fastest period of brain development falls in the last weeks of pregnancy, the nervous system of these babies needs special attention. Most grow up healthy, but the risk is higher than in the general population: cerebral palsy occurs in about 112 per 1,000 babies born before 28 weeks and about 59 per 1,000 of those born weighing 1,000–1,499 g (compared with 2 per 1,000 in the general population). That is exactly what early, scheduled follow-up is for: to spot a problem in time and not delay support.

Corrected age

Development is assessed by corrected age, not calendar age: subtract the number of weeks your baby was born before week 40. A 6-month-old born at 32 weeks has a corrected age of 4 months and is expected to have the skills of a 4-month-old. This adjustment is usually applied until age 2.

Neurological risks

  • Brain hemorrhage (intraventricular hemorrhage) and injury to the white matter (periventricular leukomalacia)
  • Cerebral palsy, motor delay, coordination problems
  • Vision (retinopathy of prematurity) and hearing disorders — both are checked on a schedule
  • Speech and cognitive delay, learning and attention difficulties at school age
  • Feeding and swallowing difficulties, reflux

The risk rises as gestational age at birth decreases and as time spent in intensive care grows longer. Severe infection in the newborn period, long ventilation and some medications also affect the outcome — these are reviewed in the epicrisis.

Follow-up schedule

Corrected ageWhat is assessed
First visit (2–4 weeks after discharge)Muscle tone, reflexes, head circumference, fontanelle, feeding, sleep; review of the epicrisis
3–4 monthsGeneral Movements Assessment (fidgety period), HINE, head control, hand function
6 monthsRolling over, early sitting, reaching for objects, sounds, social smile
9 monthsSitting, passing objects from hand to hand, turning to name, babbling
12 monthsStanding, first words, pointing, fine movements
18 and 24 monthsWalking, speech, play; autism screening at 18–24 months; corrected age applied until 24 months
Ages 3–6Speech, attention, behavior, school readiness

According to systematic reviews, among assessments done in the first 4 months, the general movements method (Prechtl GMA) best predicts later motor outcome; at 8–12 months, standard motor scales are more informative. When indicated, a brain ultrasound (until the fontanelle closes) or an MRI is ordered.

What parents can do at home

Tummy time (when awake, under supervision), talking and reading to your baby, face-to-face interaction, placing your baby on their back to sleep, keeping to the vaccination schedule (for premature babies the schedule follows chronological age), and watching feeding. Record any movement or episode that worries you on video and show it at the exam.

Frequently asked questions

My baby is normal for corrected age but behind peers

This is expected, and the gap usually closes by age 2. If there is a delay even by corrected age, the assessment is taken further.

Which babies should a neurologist follow, by gestational age?

Every baby born before 34 weeks, weighing under 1,500 g, or who spent time in intensive care should be followed on a schedule. For babies born at 34–37 weeks, at least one neurological exam is advised, followed by monitoring if concerns arise.

When can the risk of cerebral palsy be assessed?

At 3–4 months (corrected), the risk can be assessed with high accuracy using GMA and HINE and, when needed, MRI; support begins before the diagnosis is confirmed. Cerebral palsy in children

Scientific sources

The medical information on this page is based on the following peer-reviewed publications (PubMed).

  1. Oskoui M və b. (2013). An update on the prevalence of cerebral palsy: a systematic review and meta-analysis Dev Med Child Neurol. PMID 23346889
  2. Noble Y, Boyd RN (2012). Neonatal assessments for the preterm infant up to 4 months corrected age: a systematic review Dev Med Child Neurol. PMID 22142216
  3. Spittle AJ və b. (2008). A systematic review of the clinimetric properties of neuromotor assessments for preterm infants during the first year of life Dev Med Child Neurol. PMID 18190538
  4. Pires CDS və b. (2020). Predictive value of the General Movements Assessment in preterm infants: a meta-analysis Rev Paul Pediatr. PMID 32401947
  5. Novak I və b. (2017). Early, Accurate Diagnosis and Early Intervention in Cerebral Palsy: Advances in Diagnosis and Treatment JAMA Pediatr. PMID 28715518

Medically reviewed by: Dr. Aynura IbrahimovaLast updated:

The information on this page is for education only and does not replace an examination by a doctor. If you are worried about your child, book an appointment. In an emergency, call 103.

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